Research progress on the molecular mechanism of non-coding RNA regulating ferroptosis in digestive tract tumors
Ferroptosis is a recently discovered form of regulated cell death different from apoptosis,necrosis,pyroptosis and autophagy,which mainly involves three metabolic pathways namely iron metabolism,lipid peroxidation and antioxidant.It plays an important role in the occurrence,progression and drug resistance of digestive tract tumors.Non-coding RNA(ncRNA),including microRNA,lncRNA,and circRNA,regulate the expression of ferroptosis-related genes in digestive tract tumors,thereby influencing the ferroptosis pathway of tumor cells and affecting the initiation and progression of tumors.Therefore,ncRNAs play a crucial role in regulating ferroptosis in digestive tract tumors.This review summarizes the mechanisms of ferroptosis and provides an overview of ncRNA involved in regulating and modulating ferroptosis in digestive tract tumors in recent years,offering theoretical basis for the diagnosis and treatment of digestive tract tumors in the future.
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