Characteristics of vestibular evoked myogenic potentials in Parkinson's disease patients and their correlation with postural balance disorders and non-motor symptoms
Objective:To explore the characteristics of vestibular evoked myogenic potential(VEMP)in Parkinson's disease(PD)patients and analyze its correlation with postural balance disorders and non-motor symptoms.Methods:A total of 65 patients with primary PD and 60 healthy individuals(HC)matched for gender and age were included in the neurology department of the First Hospital of Hebei Medical University from June 2022 to June 2023,and all underwent VEMP examination.Unified Parkinson's disease rating scale(UPDRS)and Hoehn-Yahr staging(H-Y)were used to assess patients'motor symptoms and disease severity.Montreal cognitive assessment(MOCA),mini-mental state examination(MMSE),Hamilton depression rating scale-24(HAMD-24),Hamilton anxiety rating scale-14(HAMA-14),Pittsburgh sleep quality index(PSQI),rapid eye movement sleep behavior disorder screening questionnaire(RBD-SQ),Parkinson's disease sleep scale(PDSS),scale for outcomes in Parkinson's disease-autonomic(SCOPA-AUT),brief fatigue inventory(BFI),international restless legs scale(IRLS),Kings's Parkinson's disease pain scale(KPPS)and Wexner continence grading score(WCGS)were used to evaluate the non-motor symptoms of patients.Berg balance scale(BBS),activities balance confidence scale(ABC)and Tinetti performance oriented mobility assessment(Tinetti-POMA)were used to assess patients'postural balance disorders.Spearman correlation analysis was used to explore the correlation between VEMP and postural balance disorders and non-motor symptoms.Results:The abnormal rate of VEMP in PD patients was significantly higher than that in HC group[72.31％(47/65)vs.33.33％(20/60),x2=19.056,P＜0.001],and the abnormal pattern was mainly due to lack of response[58.46％(38/47)].Spearman correlation analysis between VEMP score and PD patient course,LEDD and various scale scores showed that VEMP score was negatively correlated with BBS score(r=-0.307,P=0.013)and Tinetti-POMA score(r=-0.255,P=0.042),and positively correlated with HAMA-14 score(r=0.323,P=0.009)and RBD-SQ score(r=0.476,P=0.001).Conclusion:The abnormal rate of VEMP in PD patients will significantly increase,and the abnormal pattern was mainly response loss.VEMP abnormalities were significantly correlated with posture balance disorders,anxiety severity,and RBD severity in PD patients.VEMP,as a non-invasive and objective neurophysiological indicator,can provide a basis for diagnosing brainstem dysfunction in PD and lay a theoretical foundation for auxiliary treatments such as vestibular stimulation and vestibular rehabilitation.
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维普
