Diagnostic value of MRI combined with serum AFP and IL-33 in primary hepatocellular carcinoma
Objective:To explore the diagnostic value of MRI parameters combined with serum AFP and IL-33 in primary hepatocellular carcinoma(HCC).Methods:Patients with HCC,intrahepatic cholangiocarcinoma or benign liver disease admitted to Guangdong Hospital of Traditional Chinese Medicine from January 1,2020 to April 1,2024 were included.106 cases of HCC,58 cases of intrahepatic cholangiocarcinoma,179 cases of benign liver disease group(59 cases of hepatic hemangioma,62 cases of hepatic cyst,58 cases of and hepatic focal nodular hyperplasia were finally included).All patients were examined by MRI and the levels of AFP and IL-33 were detected.The transport constant(Ktrans),rate constant(Kep),extracellular space volume percentage(Ve),and serum AFP and IL-33 levels were compared between the two groups.The receiver operating characteristic(ROC)curve was used to analyze the diagnostic efficacy of the above indexes alone or in combination for HCC.Results:The levels of Ktrans,Kep and Ve in HCC group were significantly higher than those in intrahepatic cholangiocarcinoma and benign liver disease group,and the difference was statistically significant(P＜0.001).The levels of serum AFP and IL-33 in HCC group were significantly higher than those in intrahepatic cholangiocarcinoma and benign liver disease group,and the difference was statistically significant(P＜0.001).ROC curve analysis showed that the optimal cut-off values of MRI parameters Ktrans,Kep and Ve in the diagnosis of HCC were 0.38 mL/min,1.32 mL/min and 0.36％.The optimal cut-off values of AFP and IL-33 for HCC diagnosis were 44.52 ng/mL and 100.81 ng/mL.The sensitivity ofKtrans,Kep,Ve,AFP and IL-33 in the diagnosis of HCC were 74.58％,74.58％,71.19％,77.12％and 77.97％,and the specificity was 74.53％,77.36％,73.58％,74.53％and 74.53％.The AUC of Ktrans,Kep,Ve combined with AFP and IL-33 in the diagnosis of HCC was 0.959(95％CI:0.936-0.982),and the predictive sensitivity and specificity were 91.53％and 90.57％.Conclusion:The combined detection of Ktrans,Kep,Ve,AFP,and IL-33 show good diagnostic efficacy of HCC,which may provide certain clinical reference value for HCC diagnosis.
万方数据
维普
