Bone homeostasis is a dynamic homeostasis process maintained by osteocytes,osteoblasts and osteoclasts,which is essential for the growth and development of bone.Protein phosphorylation and dephosphorylation can affect bone formation and development.Protein phosphatase 2A(PP2A),as an important member of the protein phosphatase family of cellular dephosphorylation,contains many subunits,has a complex structure and a wide range of functions.It can dephosphorylate proteins and participate in cellular biological processes like regulation of enzymes,transcription factors and signaling.It also plays a key role in the differentiation process of osteogenesis and osteoclasts.This review summarizes the regulatory role of PP2A in bone homeostasis and the research progress of its various inhibitors in the treatment of bone-related diseases,hoping to provide new ideas and theoretical basis for the drug treatment of bone-related diseases in clinical practice.
关键词
蛋白磷酸酶2A/去磷酸化/成骨细胞/破骨细胞/肝骨轴
Key words
protein phosphatase 2 A/dephosphorylation/osteoblast/osteoclast/hepatic bone axis
维普
万方数据