Efficacy and safety of different stimulus dosage of modified electroconvulsive therapy in the treatment of depressive episode
Objective:To investigate the efficacy and safety of different stimulus dosage of modified electroconvulsive therapy(MECT)in the treatment of depressive episode.Methods:Sixty-five patients with depressive episode according to Diagnostic and Statistical Manual of Mental Disorders,4th edition(DSM-Ⅳ)were randomly divided into treatment group(32 patients)and control group(33 patients).The patients in the treatment group received low stimulus dosage of MECT while the patients in the control group were treated with routine stimulus dosage of MECT.The treatment session was 6 times in both groups.The stimulus electrodes were placed on bifrontal.Hamilton depression scale-17 item(HAMD-17)and MATRICS consensus cognitive battery(MCCB)were used to evaluate the clinical symptoms and cognitive function at baseline,after 3 times of MECT,and after 6 times of MECT.Heart rate,systolic blood pressure,and diastolic blood pressure were recorded before and after stimulus in the first session of MECT treatment.Adverse reactions related to MECT were also recorded.Results:Fifty-six(29 patients in treatment group and 27 patients in control group)completed MECT treatment.The improvement rate of treatment group and control group was 68.97％and 70.37％,the remission rate was 51.72％and 62.96％,respectively.There was significant decrease of HAMD-17 score after MECT compared with baseline in both groups while there was no significant difference between groups.Compared with baseline,the heart rate,systolic pressure,and diastolic pressure increased significantly after stimulus in the first MECT session,while there was no significant difference between groups.There was no significant difference of MCCB score after MECT treatment compared with baseline and between groups.One patient experienced delirium in the treatment group,while in the control group,three patients experienced MECT related side effects involving headache,nausea and vomiting,muscle pain,and delirium.Conclusion:The efficacy of low stimulus dosage MECT treatment was equivalent to the conventional stimulus dosage in treating depressive episodes while with fewer adverse reactions.
万方数据
维普
