Copper(Ⅱ)phthalocyanine-catalyzed selective C(sp2)-O cross-coupling reactions of 8-aminoquinoline
Objective Developing a heterogeneous catalysis system for the selective C5(sp2)-O cross coupling of 8-aminoquinoline derivatives.Methods Optimizing the reaction from catalysts and oxidants,the scope of substrates was then investigated via the optimal conditions.Results With copper phthalocyanine as catalyst and PhI(OAC)2 as oxidant,C5 selective C-O bond was efficiently constructed in AcOH at 50℃ for 5h.Conclusion A method for C-O bond construction by means of heterogeneous catalytic system was successfully developed and applied to the selective functionalization of 8-aminoquinoline derivatives.
万方数据
