Objective Developing a heterogeneous catalysis system for the selective C5(sp2)-O cross coupling of 8-aminoquinoline derivatives.Methods Optimizing the reaction from catalysts and oxidants,the scope of substrates was then investigated via the optimal conditions.Results With copper phthalocyanine as catalyst and PhI(OAC)2 as oxidant,C5 selective C-O bond was efficiently constructed in AcOH at 50℃ for 5h.Conclusion A method for C-O bond construction by means of heterogeneous catalytic system was successfully developed and applied to the selective functionalization of 8-aminoquinoline derivatives.
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