Association analysis of DGKZ rs7951870 polymorphism with schizophrenia in Chinese Han population
Objective This study aimed to explore the association between the single nucleotide polymorphisms(SNPs)of DGKZ and susceptibility to schizophrenia in Chinese Han population.Methods Collect peripheral venous blood and extract whole genome DNA.DNA from 239 healthy controls and 211 schizophrenic patients was genotyped for SNPs rs7951870 in DGKZ using a predesigned TaqMan SNP genotyping assay.From February 2018 to May 2019.Results No significant differences in allelic or genotypic frequencies of DGKZ rs7951870 were detected between cases and controls(DGKZ rs7951870:χ2=2.67,P=0.26 by genotype,χ2=1.07,P=0.30.On the basis of additive,dominant and recessive model analysis,rs7951870 is not a risk factor for SCZ(P>0.05).Conclusion Our results suggest that DGKZ rs7951870 SNPs are unlikely to play a major role in the pathogenesis of schizophrenia in Shandong Han popula-tion.However,these results should be validated by replication in larger and independent samples.
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