胃癌上皮间质转化相关LncRNA研究进展
Progress in the study of LncRNA associated with epithelial mesenchymal transition in gastric cancer
王阳 1张保贵2
作者信息
- 1. 济宁医学院临床医学院,济宁 272013
- 2. 济宁医学院附属医院胃肠外科,济宁 272029
- 折叠
摘要
上皮间质转化(EMT)被认为是肿瘤侵袭转移的关键步骤.LncRNA是一种不编码蛋白质的RNA,它的主要功能是通过调节基因转录相关的复合物活性及其他复杂机理控制下游基因的转录和表达,其中包括EMT过程中相关信号通路.EMT与胃癌的原发浸润、继发侵袭和转移关系密切.本文对胃癌EMT相关的Ln-cRNA的研究进展进行综述.
Abstract
Epithelial mesenchymal transformation(EMT)refers to the biological process of transforming epithelial cells into cells with mesenchymal phenotype.It is considered to be a key step in tumor invasion and metastasis.LncRNA is a kind of RNA that does not encode protein.Its main function is to control the transcription and expression of down-stream genes by regulating the complex activity related to gene transcription and other complex mechanisms,including related signal pathways in the process of EMT.Studies have shown that EMT is closely related to the primary invasion,secondary invasion and metastasis of gastric cancer.This paper reviews the research progress of EMT related LncRNA in gastric cancer.
关键词
胃癌/长链非编码RNA/EMTKey words
Gastric cancer/Lnc RNA/EMT引用本文复制引用
基金项目
济宁市重点研发计划项目(2020YXNS004)
出版年
2024
NETL
NSTL
万方数据