Synthesis of gelatin/hydroxypropyl β-cyclodextrin/glycerol water composite gel and its bacteriostatic performance as drug delivery system
Objective A gelatin(GA)gel modified by hydroxypropyl β-cyclodextrin(HPCD)will be synthesized,and its micro-structure,physical properties,antibacterial effect of loaded-drug levofloxacin(LVFX)will also be investi-gated.Methods The composite gel was synthesized by sol-gel method,and its structure and properties were studied by OM,SEM,FTIR,XRD and rheology.The antibacterial effect of the composite gel loaded with levofloxacin was tested by Oxford cup method.Results The GA spiral molecules could be collected by H-bond force of HPCD,which enhanced the stability of the composite gel network and increased the stress yield value of 1000 pa.The antibacterial efficacy of the loaded-drug gel with LVFX could reach about 90.27%and 80.02%to the positive antibacterial control on Staphylococ-cus aureus and Escherichia coli,respectively.Conclusion The composite gel can be acquired in a direct and easy method.The microstructure and properties of GA/HPCD gel were optimized by H-bonding interactions between GA and HPCD or glycerol molecules.The composite gel deserves to be widely applied as drug delivery system.