Effect of carprost tromethamine on coagulation factors in patients at high risk for postpartum hemorrhage
Objective To analyze the clinicaleffect and effect on coagulation factors of carprost trometamol on the bed width and coagulation factors in patients with high risk of postpartum hemorrhage.Methods A total of 118 patients with high risk of postpartum hemorrhage from September 2016 to September 2022 in Jining Maternal and Child Health Care and Family Planning Service Center were randomly divided into observation group and control group,59 cases in each group.The patients in the observation group were treated with intravenous injection of 20u of uterine oxytocin plus 0.6mg misopreliol oral administration,while those in the control group were treated with intravenous injection of 20u lioxytocin plus intravenous injection of capprost trometamol 250ug intrau-terine or intramuscular injection of hip.The postpartum hemorrhage,coagulation factors,coagulation function and average hemostatic time were compared between the two groups.Results The amount of maternal bleeding at 2h in the observation group were lower than those in the control group.There was no significant difference in the comparison of the difference in blood loss between 24 hours and 2 hours postpartum.Both groups showed improvement in coagulation factors and coagulation function after treatment.FⅦ,FⅧ,FⅨ and FIB of the observation group were significantly higher than those in the control group,while PT and APTT were lower than those in the control group(P<0.05)and the FIB was significantly higher than that of the control group(P<0.05).The average hemostasis time of the observation group was significantly lower than that of the control group(t=9.79,P<0.001).There was no statistically significant difference in the incidence of adverse reactions between the two groups of parturients(P>0.05).Conclusion Carprost trometamol can reduce the rate of postpartum hemorrhage,regulate coagulation factors and improve coagulation function in patients with high risk of postpartum hemorrhage.
Carprost tromethamineHigh-risk pregnant womenPostpartum hemorrhageCoagulation factorsCoagu-lation function
万方数据
维普
