Vasoplegia is the syndrome of pathological low systemic vascular resistance,characterized mainly by hypotension and low responsiveness to vasopressors.There are many causes of vasoplegia,and the most common is sep-sis,followed by cardiac surgery,vasoplegia after surgery is called vasoplegic syndrome.Non-cardiac surgery,burns,trau-ma,pancreatitis,some drugs can also lead to vasoplegia.Vasoplegia lacks a uniform clinical definition and has a complex pathophysiology involving the release of endothelial-derived relaxing factors,overactivation of ATP-sensitive potassium channels,disruption of balance between prostacycline and thromboxane A2,overproduction of oxygen free radicals and so on.The understanding of these mechanisms provides additional options for the treatment of vasoplegia.Currently,norepi-nephrine,the first choice for the treatment of vasoplegia after volume resuscitation,may produce some side effects,and the emergence of second-line drugs like vasopressin portends greater potential for the treatment of vasoplegia.
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