Progress in the mechanism of vasomplegia in patients with septic shock
Vasoplegia is the syndrome of pathological low systemic vascular resistance,characterized mainly by hypotension and low responsiveness to vasopressors.There are many causes of vasoplegia,and the most common is sep-sis,followed by cardiac surgery,vasoplegia after surgery is called vasoplegic syndrome.Non-cardiac surgery,burns,trau-ma,pancreatitis,some drugs can also lead to vasoplegia.Vasoplegia lacks a uniform clinical definition and has a complex pathophysiology involving the release of endothelial-derived relaxing factors,overactivation of ATP-sensitive potassium channels,disruption of balance between prostacycline and thromboxane A2,overproduction of oxygen free radicals and so on.The understanding of these mechanisms provides additional options for the treatment of vasoplegia.Currently,norepi-nephrine,the first choice for the treatment of vasoplegia after volume resuscitation,may produce some side effects,and the emergence of second-line drugs like vasopressin portends greater potential for the treatment of vasoplegia.
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