The mechanism of traditional Chinese medicine taohuang formula in treating schizophrenia
Objective To explore the mechanism of action of the effective ingredients of Taohuang Formula(Taoren-Dahuang-Chishao)in the treatment of schizophrenia(SCZ)using network pharmacology and molecular docking technology.Method The main components of Taohuang Formula and the targets related to SCZ were screened through public databases.The intersection genes between drugs and diseases were selected to construct a protein-protein interac-tion network(PPI),and core targets were selected based on the strength of the interaction.A drug-effective ingredient-common targets for drug-disease was constructed.Perform gene GO functional analysis and KEGG pathway enrichment analysis on intersection targets.Perform molecular docking analysis on the main active ingredients and core targets using AutoDock software.Result Taohuang Formula acts on 60 SCZ related targets through 44 effective ingredients.Mainly through Compounds such as sitosterol,baicalin,stigmasterol,aloe emodin,ellagic acid,ivy,etc.act on multiple targets such as TNF,VEGFA,CASP3,AKT1,TP53,PTGS2,and intervene in SCZ by participating in regulating the P13K-AKT signaling pathway and MAPK signaling pathway.The molecular docking results showed good docking between the key active ingredients and the core target,among which stigmasterol had the optimal binding energy with PTGS2,which was-10.1kcal/mol.Conclusion Taohuang Formula has played a good role in the treatment of SCZ through multiple targets and pathways,providing a theoretical basis for the pharmacological mechanism of Taohuang Formula in treating schizophrenia.
万方数据
维普
