Effects of intravenous dexmedetomidine combined with lidocaine on postoperative analgesia and cognitive function in patients undergoing thoracoscopic surgery
Objective To explore the effects of intravenous injection of dexmedetomidine combined with lidocaine on postoperative analgesia and cognitive dysfunction in patients undergoing thoracoscopic surgery.Methods A total of 180 patients requiring thoracoscopic surgery in Xinxiang First People's hospital from July 2021 to July 2023 were ran-domly divided into three groups according to the numerical table method.Group A:dexmedetomidine group(n=60);Group B:lidocaine group(n=60);Group C:dexmedetomidine combined with lidocaine(n=60),visual analogue score(VAS),simple mental state Examination Scale(MMSE)were compared at 6h,12h,24h and 48h,respectively.Results The VAS scores at T1,T2,T3 and T4 in group C were lower than those in groups A and B,and the scores in group A were lower than those in group B(P＜0.05).The levels of postoperative inflammatory factors at T2,T3 and T4 in group C were lower than those in groups A and B(P＜0.05),and the levels of postoperative inflammatory factors in group A were lower than those in group B(P＜0.05).The cognitive function scores of group C were higher than those of group A and group B at 6h,12h,24h and 48h after operation(P＜0.05),but there was no significant difference between group A and group B(P＞0.05).The above results all indicate that there are significant differences in VAS,MMSE be-tween different groups and different time points.Conclusion Intravenous injection of dexmedetomidine combined with lidocaine in patients undergoing thoracoscopic surgery can not only reduce postoperative pain.
DexmedetomidineLidocaineThoracoscopic surgeryAnalgesic effectCognitive function
万方数据
维普
