Predictive value of interleukin-32 on heart failure after acute myocardial infarction
Objective To investigate the relationship and the predictive value of interleukin-32(IL-32)in heart failure(HF)after acute myocardial infarction(AMI).Methods 100 patients with AMI hospitalized in our hospital from January to June 2021 were selected as research objects.The expression levels of serum IL-32,interleukin-6(IL-6)and matrix metalloproteinase-9(MMP-9)within AMI 12 hours were measured by ELISA,and the B-type natriuretic pep-tide(BNP),left ventricular ejection fraction(LVEF)and left ventricular end-diastolic inner diameter(LVEDD)were measured with AMI 6 months after onset.According to LVEF,patients were divided into heart failure group(LVEF<50%,n=35)and control group(LVEF≥50%,n=65).The risk factors of heart failure after AMI were analyzed by univariate and multivariate logistic regression.The predictive value of IL-32 for HF was analyzed by the receiver operat-ing curve(ROC).Results The proportion of hypertension,IL-32 expression level,BNP and LVEDD in the heart failure group were significantly higher than those in the control group(P<0.05),and the total cholesterol was lower than that in the control group.After myocardial infarction,IL-32 expression was positively correlated with IL-6 expression,LVEDD,and BNP(r1=0.249,P=0.016;r2=0.286,P=0.010;r3=0.448,P=0.001),and was negatively correlated with LVEF(r4=-0.752,P=0.001).Multivariate logistic regression analysis showed that IL-32(OR=1.077,95%CI=1.028～1.127,P=0.002),BNP(OR=1.002,95%CI=1.000～1.004,P=0.024)were independent risk factors for HF after AMI.The area under the ROC curve(AUC)of IL-32 in predicting heart failure after AMI was 0.832(95%CI=0.738～0.926,P<0.05),the diagnostic sensitivity was 0.697 and the specificity was 0.918,the best cut-off value was 50.219pg/mL.The AUC of IL-32 plus BNP in predicting heart failure after AMI was 0.894(95%CI=0.825～0.964,P<0.05),with a sensitivity of 0.667 and specificity of 0.954.Conclusion IL-32 expression was significantly increased in patients with heart failure after AMI.IL-32 has certain application value in predicting cardiac insufficiency after AMI.
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