Correlation of neutrophil lymphocyte ratio with preeclampsia in the second trimester of pregnancy
Objective To investigate the differential relationship between neutrophil/lymphocyte ratio(NLR)in mild preeclampsia,severe preeclampsia and healthy pregnant women in the second trimester,and the potential value of NLR in screening for preeclampsia and predicting the severity of its disease development.Methods A total of 1115 pregnant women were selected from the Affiliated Hospital of Jining Medical University from January 1,2018 to January 30,2021,including 395 cases of mild preeclampsia and 339 cases of severe preeclampsia,and 381 cases of normal preg-nant women hospitalized.At the same time,the patient's age,BMI,peripheral blood NLR,systolic and diastolic blood pressure were collected to explore the relationship between preeclampsia and NLR.Results NLR in peripheral blood of preeclampsia pregnant women(including mild and severe preeclampsia pregnant women)was significantly higher than that of healthy pregnant women.Moreover,NLR was significantly higher in patients with severe preeclampsia than in patients with mild preeclampsia(P<0.001).After adjusting for variables such as BMI,age,and blood pressure,NLR was still found to be an independent risk factor for preeclampsia(OR=2.814,95%CI=2.130～3.717).Conclusion The increase of NLR in peripheral blood during the second trimester of pregnancy is an independent risk factor for preeclampsia.Therefore,NLR may be predictive of the occurrence of preeclampsia.
PreeclampsiaNeutrophils/lymphocytesSecond trimester of pregnancyDisease prediction
NETL
NSTL
万方数据
