Small molecule compound G-749 suppresses the proliferation and migration of gastric cancer cells
Objective To investigate the effects of small molecule compound G-749 on the proliferation and migration of human gastric cancer cells MGC803 and SGC7901.Methods MGC803 and SGC7901 human gastric cancer cells were treated with different concentrations of G-749.CCK8 assay and colony formation assay were used to detect the effect of G-749 on the proliferation of gastric cancer cells.Flow cytometry was used to check the effect of G-749 on the cell cycle.The scratch test was used to identity the effect of G-749 on the migration of gastric cancer cells.Results The compound G-749 inhibited the proliferation of human gastric cancer cells MGC803 and SGC7901 in a dose-dependent manner,and inhibited the transition of cells from G0/G1 phase to S phase,and suppressed the migration of gastric cancer cells.Conclusion Compound G-749 has inhibitory effect on gastric cancer cells and is expected to be used in the treatment of gastric cancer cells.
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