Correlation study of the expression,prognosis and malignant progression of NCAPH in glioma
Objective To investigate the expression,prognosis and biological function of non-SMC adhesion protein Ⅰ subunit H(NCAPH)in glioma.Methods The expression profiles of NCAPH were downloaded and analyzed by TCGA and GTEx databases;the relationship between NCAPH expression and patient prognosis was analyzed by KM survival analysis and COX regression;the biological functions that NCAPH may be involved in were analyzed by GSEA;the relationship between NCAPH expression and immune microenvironment was analyzed by ssGSEA;and the expression level of NCAPH in clinical specimens was detected by RT-qPCR.Results The expression level of NCAPH in glioma was increased,and was related to the prognosis of patients and the malignant progression of tumors.The expression level of NCAPH increased with the increase of WHO grade of tumors,and the expression level of NCAPH in IDH-1 wild-type patients was higher than that in mutant patients.NCAPH may be involved in biological functions such as tumor proliferation,migration,tumor-promoting inflammation.NCAPH was positively correlated with Th2 cells and macrophages in tumor microenvironment,but not with other cells.Conclusion The expression level of NCAPH in glioma was increased,and NCAPH can be used as a prognostic marker and therapeutic target for glioma patients.
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