摘要
环状RNA(circRNA)为一种共价键形成闭合环状结构的内源性非编码RNA,能吸附微小RNA、调控基因表达、调控蛋白质的生成、作为生物标志物等.病理性心肌肥厚是由心肌梗死、机械刺激、激素、细胞因子、生长因子和压力超负荷等因素引起的,其发病机制复杂,受多种细胞信号调控,其中包括新兴的circRNA等非编码RNA调控.某些circRNA的上调或下调可以促进或抑制病理性心肌肥厚,其作用方式主要集中于circRNA充当miRNA的内源性海绵吸附靶基因,进而影响心肌肥厚相关的信号通路蛋白.本文旨在对circRNA的生物学研究、病理性心肌肥厚的形成机制以及circRNA在病理性心肌肥厚中的研究新进展进行综述.
Abstract
Circular RNA(circRNA)is an endogenous non-coding RNA with a closed circular structure formed by covalent bonds,which can adsorb microRNA,regulate gene expression,regulate protein production,and act as biomarkers.Pathological myocardial hypertrophy is caused by myocardial infarction,mechanical stimulation,hormones,cytokines,growth factors,and pressure overload.Its pathogenesis is complex and regulated by a variety of cell signals,including the emerging circRNA and other non-coding RNAs.The up-regulation or down-regulation of certain circRNAs can promote or inhibit pathological myocardial hypertrophy,and its mode of action mainly focuses on circRNAs acting as endogenous sponge adsorption target genes of miRNAs,and then affecting signaling pathway proteins related to myocardial hypertrophy.This article aims to review the biological research of circRNA,the formation mechanism of pathological myocardial hypertrophy,and the new research progress of circRNA in pathological myocardial hypertrophy.
基金项目
国家自然科学基金(32271160)
国家自然科学基金(31500930)
2022年辽宁省大学生创新训练项目(省级)
2022年辽宁省大学生创新训练项目(S202210159055)
辽宁省教育厅科学研究项目(JCZR2020021)
NETL
NSTL
万方数据