Spock1参与Adipogenesis通路在肥大型与扩张型心肌病中的机制探讨
The mechanism of Spock1 involved in Adipogenesis pathway in hypertrophic and dilated cardiomyopathy
朱荣利 1刘颖 2柳明 3易玮珏 1吴凤敏 1侯秀阳 1封瑞1
作者信息
- 1. 中国医科大学药学院药物毒理学教研室,辽宁沈阳 110122
- 2. 辽宁省基础医学研究所 医学生物技术教研室,辽宁沈阳 110101
- 3. 天津海关工业产品安全技术中心,天津 300308
- 折叠
摘要
目的 探讨SPARC(骨素)、cwcv和Kazal样结构域蛋白多糖1(Spock1)在肥大型与扩张型心肌病发生中的作用与分子机制.方法 基于CNKI数据库明确Spock1在机体各组织中的表达情况,并获得Spock1参与信号通路的关联基因,对此关联基因进行GO和KEGG富集分析,对比同类基因与心脏疾病的关系,从而分析获得Spock1参与肥大型与扩张型心肌病的具体关联信息.结果 Spock1在心脏中较高表达,并且其可能通过Adipogene-sis信号通路参与肥大型心肌病(HCM)和扩张型心肌病(DCM)的发生与发展.结论 Spock1可能与肥大型和扩张型心肌病等相关心血管疾病的发生密切相关,并可能成为心脏疾病发生发展的生物标记物,甚至可成为治疗心脏疾病的新靶点基因.
Abstract
Objective To investigate the role and molecular mechanism of SPARC(osteocalcin),cwcv and Kazal-like domain protein polysaccharide 1(Spock1)in the occurrence of hypertrophic and dilated cardiomyopathy.Methods Based on CNKI database,the expression of Spock1 in various tissues of the body was clarified,and the associated genes of Spock1 participating in the signaling pathway were obtained,and the GO and KEGG enrichment analysis were performed on the associated genes to compare the relationship between similar genes and heart disease,so as to obtain specific association information of Spock1 in hypertrophic and dilated cardiomyopathy.Results Spock1 was highly expressed in the heart,and it may be involved in the occurrence and development of hypertrophic cardiomyopathy(HCM)and dilated cardiomyopathy(DCM)through adipogenesis signaling pathway.Conclusion Spock1 may be closely related to the occurrence of hypertrophic and dilated cardiomyopathy and other cardiovascular diseases,and may become a biomarker for the occurrence and development of heart disease,or even a new target gene for the treatment of heart disease.
关键词
Spock1/信号通路/心脏疾病/富集分析Key words
Spock1/signaling pathway/heart disease/enrichment analysis引用本文复制引用
基金项目
国家自然科学基金(31400981)
辽宁省教育厅科学研究经费项目(L202003)
大学生创新创业训练计划(2020)(x202010159044)
出版年
2024
NETL
NSTL
万方数据