The research progress on the role of calcium homeostasis and autophagy in myocardial hypertrophy
Myocardial hypertrophy refers to the increase in the mass and volume of the myocardium that occurs under the influence of various factors.Physiologic myocardial hypertrophy can transform into pathological myocardial hypertrophy,eventually leading to heart failure and sudden cardiac death.The pathological factors of myocardial hypertrophy are complex,calcium homeostasis and autophagy play an important role in the occurrence and development of myocardial hypertrophy.Calcium signaling mainly includes calcium/calmodulin/calmodulin-dependent protein kinase Ⅱ/myocyte enhancer factor-2(Ca2+/CaM/CaMK Ⅱ/MEF-2)and calcium/calmodulin/calmodulin-dependent protein kinase Ⅱ/calcineurin/nuclear factor of activated T cell(Ca2+/CaM/CaMK Ⅱ/CaN/NFAT),while calcium homeostasis and autophagy are also mutually regulated.This article reviews the roles of calcium homeostasis and autophagy in myocardial hypertrophy.
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