摘要
心肌肥厚指心脏在各种因素作用下出现的心肌质量和体积的增加.生理性心肌肥厚可以转变为病理性心肌肥厚,最终导致心力衰竭和心源性猝死.心肌肥厚病理因素较为复杂,钙稳态和自噬在心肌肥厚的发生发展中起着重要作用.钙信号主要包括钙离子/钙调蛋白/钙调素依赖蛋白激酶Ⅱ/肌细胞增强因子-2(Ca2+/CaM/CaMKⅡ/MEF-2)和钙离子/钙调蛋白/钙调素依赖蛋白激酶Ⅱ/钙调神经磷酸酶/活化T细胞核因子(Ca2+/CaM/CaMKⅡ/CaN/NFAT)两条通路,同时钙稳态与自噬两种途径也互相调节.本文对钙稳态和自噬在心肌肥厚中的作用作一综述.
Abstract
Myocardial hypertrophy refers to the increase in the mass and volume of the myocardium that occurs under the influence of various factors.Physiologic myocardial hypertrophy can transform into pathological myocardial hypertrophy,eventually leading to heart failure and sudden cardiac death.The pathological factors of myocardial hypertrophy are complex,calcium homeostasis and autophagy play an important role in the occurrence and development of myocardial hypertrophy.Calcium signaling mainly includes calcium/calmodulin/calmodulin-dependent protein kinase Ⅱ/myocyte enhancer factor-2(Ca2+/CaM/CaMK Ⅱ/MEF-2)and calcium/calmodulin/calmodulin-dependent protein kinase Ⅱ/calcineurin/nuclear factor of activated T cell(Ca2+/CaM/CaMK Ⅱ/CaN/NFAT),while calcium homeostasis and autophagy are also mutually regulated.This article reviews the roles of calcium homeostasis and autophagy in myocardial hypertrophy.
基金项目
国家自然科学基金(32271160)
国家级大学生创新训练项目(202210159002)
NETL
NSTL
万方数据