The progress of mitochondrial quality control in myocardial protection
Mitochondria are essential organelles for cell metabolism and energy production,and play an important role in maintaining heart homeostasis.Cardiomyocytes mitochondrial dysfunction can lead to cardiovascular diseases such as heart failure,cardiomyopathy,and cardiac ischemia/reperfusion injury.Mitochondrial quality control(MQC)is an important mechanism for eukaryotic cells to maintain the relative stability of number and function of mitochondria,including mitophagy,mitochondrial fusion and division,mitochondria-associated degradation,and mitochondrial protein translocation-associated degradation.Therefore,mitochondrial quality control plays a vital role in maintaining cardiomyocytes mitochondrial homeostasis under physiological or pathological conditions.
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