Curcumin attenuates gastric mucosal inflammatory response and oxidative stress in helicobacter pylori-infected mice via PI3K/AKT signaling pathway
Objective To investigate the effects of curcumin on gastric mucosal inflammation and oxidative stress in Helicobacter pylori infected mice and its possible mechanism.Methods Thirty male BALB/C mice were randomly divided into control group,infection group and curcumin group,with 10 mice in each group.The pathological changes of gastric mucosa were detected by HE staining.The levels of 16s rRNA,SS1,ureA and SSA mRNA in gastric mucosa were detected by qRT-PCR.The levels of SOD,CAT,MDA,IL-1β,IL-8 and TNF-α in serum were detected by ELISA.The expressions of p-PI3K,PI3K,AKT and p-AKT were detected by Western blot.Results The degree of inflammatory damage in gastric mucosa,the expression levels of virulence factors,inflammatory response in serum and oxidative stress,and the expressions of p-PI3K and p-AKT in H.pylori-infected mice models were significantly higher than those in the control group.Curcumin reduced inflammatory response and inhibits oxidative stress in the gastric mucosa of helicobacter pylori-infected mice,down-regulated the expressions of p-PI3K and p-AKT.Conclusion Curcumin could reduce gastric mucosal inflammation and oxidative stress in H.pylori infected mice by inhibiting PI3K/AKT signaling pathway.
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