Quinazoline PAK4 small molecule inhibitor CWS1 inhibits lung cancer cell migration and invasion
Objective To investigate the effect of quinazoline PAK4 small molecule inhibitor CWS1 on migration of lung cancer cells.Methods The effects of different concentrations of CWS1 on lung cancer cell migration were detected by scratch test.Transwell assay was used to detect the effects of CWS1 on the invasion of lung cancer cells.The effect of CWS1 on the activation of PAK4 kinase in lung cancer cells was detected by Western blot assay.Results CWS1 significantly inhibited the migration of lung cancer cells,and 2 μmol/L CWS1 obviously inhibited the migration and invasion ability of lung cancer cells.CWS1 could inhibit the phosphorylation activity of PAK4 kinase in a dose-time effect relationship.Conclusion CWS1 inhibits the migration and invasion of lung cancer cells by inhibiting PAK4 kinase activity.
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