Objective To investigate the association between the index finger and ring finger length ratio(2D∶4D)and of four loci(rs6461992,rs6968828,rs7801581,rs17427875)polymorphism of homeobox(HOX)A11 gene among Ningxia college students.Methods Digit camera was used to collect frontal hand photos of 667 Han college students(348 males and 319 females)from Ningxia province;Image analysis software was used to mark the anatomical points and measure finger lengths of the index and ring fingers of both hands;multiplex PCR was used to detect each locus polymorphisms of HOXA11 gene;statistical software was used to compare and analyze the differences and associations of 2D∶4D and gene polymorphisms between different genders.Results Among Ningxia Han college students,both left hand and right hand 2D∶4D were significantly higher in females than those of in males(all P＜0.05),and there were no significant sex differences in right-left hand 2D∶4D;the genotypes and allele frequencies of rs7801581 locus of HOXA11 gene differed significantly between genders(all P＜0.05),and none of the other locus polymorphisms showed any significant sex differences;only female left hand 2D∶4D was significantly associated with rs6461992 locus genotype in the relationship between 2D∶4D and HOXA11 polymorphisms(P＜0.05).Conclusion There were significant sex differences in 2D∶4D among Han college students in Ningxia,and the rs6461992 locus polymorphism of HOXA11 gene may be associated with the formation of 2D∶4D in females.
关键词
同源盒A11基因/示指/环指/指长比/多重聚合酶链反应/宁夏大学生
Key words
Homeobox A11 gene/Index finger/Ring finger/Digit ratio/Multiplex PCR/Ningxia college student
维普
万方数据