Current progress of metal ions in the pathogenesis of refractory epilepsy
Epilepsy is a common chronic neurological disorder caused by abnormal electrical activity in the brain,and its pathogenesis has not been fully clarified.In recent years,more and more studies have shown that iron,zinc and copper in the brain are involved in the occurrence and development of epilepsy.These metal ions possibly play a role in epileptogenesis by affecting neuronal excitability and signal transduction through alterating ion channel function,potential balance,action potential propagation,redox and so on.In this review,we mainly analyse the effects of these metal ions on epilepsy,in order to explore the underlying mechanisms of epilepsy and provide promising therapeutic strategies for epilepsy based on metal ions.
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