金属离子在难治性癫痫发病机制中的研究进展
Current progress of metal ions in the pathogenesis of refractory epilepsy
李昊 1张莹 2刘媛媛1
作者信息
- 1. 广西医科大学基础医学院,南宁 530021;广西脑科学研究重点实验室,南宁 530021
- 2. 广西职业技术学院,南宁 530226
- 折叠
摘要
癫痫是一种常见的由大脑异常电活动引起的慢性神经系统疾病,其发病机制尚未完全阐明.近年来有越来越多研究证明,大脑中的铁、锌、铜参与癫痫的发生发展过程,可能通过影响相应的离子通道的功能、膜电位的平衡、动作电位的传导、氧化还原等方面,进而影响神经元的兴奋性和信号传导.本文中我们就此进行综述,旨在增进我们对癫痫发病机制的理解,为寻找基于金属离子防治癫痫策略提供新思路.
Abstract
Epilepsy is a common chronic neurological disorder caused by abnormal electrical activity in the brain,and its pathogenesis has not been fully clarified.In recent years,more and more studies have shown that iron,zinc and copper in the brain are involved in the occurrence and development of epilepsy.These metal ions possibly play a role in epileptogenesis by affecting neuronal excitability and signal transduction through alterating ion channel function,potential balance,action potential propagation,redox and so on.In this review,we mainly analyse the effects of these metal ions on epilepsy,in order to explore the underlying mechanisms of epilepsy and provide promising therapeutic strategies for epilepsy based on metal ions.
关键词
癫痫/金属离子/神经系统/离子通道/螯合治疗Key words
Epilepsy/Metal ion/Nervous system/Ion channel/Chelation therapy引用本文复制引用
基金项目
国家自然科学基金(82060253)
广西高校中青年教师科研基础能力提升项目(2020KY29021)
广西高校中青年教师科研基础能力提升项目(2021KY0117)
出版年
2024
NETL
NSTL
万方数据