The role of fructose in the pathogenesis of hepatic insulin resistance
With economic development,diabetes has become one of the most common chronic diseases globally,and liver insulin resistance is one of the key factors for the occurrence and development of type 2 diabetes mellitus.This paper reviews the studies on the direct effects of fructose on insulin pathway and the indirect blocking of insulin pathway through increasing de novo synthesis of liver lipids,weakening fatty acid oxidation in hepatocytes,activating oxidative stress in hepatocytes,and enhancing hepatic inflammatory responses.It provides a new perspective for the diagnosis and treatment of obesity,type 2 diabetes and other diseases closely related to hepatic insulin resistance.
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