摘要
前交叉韧带损伤是运动医学领域常见的韧带损伤之一.由于其内源性修复能力有限,重建术成为首选治疗方法.然而,术后韧带功能难以完全恢复,术后容易出现多种并发症,降低患者生活质量.随着韧带修复经验的积累以及组织工程和再生医学的发展,非手术重建方法和生物增强技术成为研究热点,特别在动物模型中得到广泛应用,以探索改善前交叉韧带损伤修复效果的治疗途径.现对促进前交叉韧带内源性修复的基础研究进展,从生长因子疗法、干细胞疗法、基因治疗、生物工程学、药物治疗、物理治疗等6个方面进行综述.
Abstract
Anterior cruciate ligament(ACL)injury is one of the common ligament injuries in the field of sports medicine.Due to its limited endogenous repair capacity,reconstruction surgery has become the preferred treatment method.However,postoperative ligament function is difficult to fully restore,and various complications are prone to occur,which can reduce the patient's quality of life.With the accumulation of experience in ligament repair and the development of tissue engineering and regenerative medicine,non-operative reconstruction methods and biological enhancement techniques have become research hotspots,especially in animal models,to explore treatment approaches that improve the effectiveness of anterior cruciate ligament injury repair.This article reviews the progress of basic research promoting endogenous repair of the anterior cruciate ligament,which can be summarized into six aspects:growth factor therapy,stem cell therapy,gene therapy,bioengineering,pharmacological therapy,and physical therapy.
基金项目
沈阳市科技计划项目资金(20-205-4-078)
辽宁省科学技术厅支持中国医科大学高质量发展科技资金项目(2023JH2/20200135)
国家科技期刊平台
NSTL
万方数据