Association between the digit ratio(2D︰4D)and single nucleotide polymorphisms of collagen gene family
Objective:To investigate the association of the digit ratio(2D︰4D)with ten single nucleotide polymorphism sites(rs3809346,rs3825490,rs7984100,rs1134170,rs3128575,rs1042917,rs2839110,rs3812111,rs1064583,rs2228547)in four genes(COL4A2,COL5A1,COL6A2,COL10A1)of collagen gene family.Methods:The distribution characteristics of 2D︰4D and COL4A2,COL5A1,COL6A2,and COL10A1 genes polymorphisms among college students in Ningxia Hui Autonomous Region were compared by using physical measurement and multiplex PCR,respectively,and the association between them was analyzed.Results:The mean 2D︰4D of both hands were significantly higher in Ningxia female college students than that in males.There were no significant sex differences in the genotype and allele distribution frequencies of the ten loci.The COL4A2 rs3825490 and rs3809346 loci genotypes were significantly associated with 2D︰4D of both hands in males and females,respectively,and the genotypes of COL5A1 rs1134170 and COL6A2 rs1042917 loci were significantly associated with 2D︰4D in left hand of females and 2D︰4D in right hand of males,respectively.Conclusion:The formation of 2D︰4D in Ningxia population may be related to the polymorphisms of COL4A2(rs3809346,rs3825490),COL5A1(rs1134170),and COL6A2(rs1042917)genes.
万方数据
维普
