Role of lymphangiogenesis in the repair and regeneration of myocardial injury
Due to the lack of regeneration ability of mature cardiomyocytes,the key points for myocardial infarction therapy is to reduce cardiomyocyte death after myocardial ischemia and promote myocardial regeneration.An increasing number of studies suggest that lymphatic drainage plays a crucial role in the process of myocardial regeneration.After myocardial infarction,promoting the generation of lymphatic vessels can control and reduce the inflammatory reaction in time,which is conducive to the repair and regeneration of the heart.On the contrary,if the lymphatic vessel function is defective,the myocardial edema and fibrosis will be aggravated.Therefore,it is very important to understand the process and mechanism of cardiac lymphangiogenesis.This article reviews the basic structure,origin,and function of cardiac lymphatic vessels,the role of lymphatic drainage after myocardial injury,and summarizes several molecular mechanisms related to lymphangiogenesis,hoping to provide potential way to promote myocardial regeneration from the perspective of the lymphatic system.
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