Research progress on crosstalk between decidual macrophages and trophoblast cells at the maternal-fetal interface in spontaneous miscarriage
Spontaneous miscarriage is characterized by a highly intricate pathogenesis.An increasing body of research suggests an association between unexplained spontaneous miscarriage and the immune microenvironment at the maternal-fetal interface.Among immune cells,decidua macrophages(DM),originating from the mother,rank as the second most abundant.These macrophages play a crucial role in reshaping spiral arteries,sustaining maternal-fetal immune tolerance,and modulating the biological behavior of trophoblasts.Trophoblasts,being the only embryonic cells in direct contact with maternal decidua,contribute significantly to maternal-fetal immune tolerance,exhibiting behaviors akin to the migration and invasion observed in tumor cells.Studies indicate an intricate intercellular crosstalk between DM and trophoblasts.DM influence the migration and invasion capabilities of trophoblasts,while trophoblasts,in turn,regulate the polarization of DM.Notably,abnormal crosstalk between these entities at the maternal-fetal interface is observed in individuals experiencing spontaneous miscarriage.This article systematically expounds on the functions of DM and trophoblasts,emphasizing the impact of irregular crosstalk between the two on natural miscarriage.By delving into the intricacies of the maternal-fetal interface,the aim is to establish a theoretical foundation for comprehending the pathogenesis of natural miscarriage and identifying novel therapeutic targets.
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维普
