纳米颗粒介导冷冻消融治疗肿瘤的研究进展
Research progress in nanoparticle-mediated cryoablation therapy for tumors
王辅明 1杨继金1
作者信息
- 1. 200433 上海 海军军医大学附属长海医院介入科
- 折叠
摘要
冷冻消融术是一种基于低温的局部消融方式,被广泛应用于全身实体瘤的治疗.冷冻效率不高和精准度不够是当前冷冻消融术亟待解决的难题.随着纳米科学的不断进步,各种类型的纳米颗粒被开发应用,加载至目标区域可以显著提高冷冻效率,同时具备靶向传递药物以及图像增强等功能,为突破冷冻消融当前的临床应用瓶颈提供了可能.本文主要回顾了当前研究应用于介导冷冻消融术的几种常见纳米颗粒的主要功能以及作用机制,希望对该领域有更加全面的认识,为下一步深化研究和实现临床转化打牢基础.
Abstract
Cryoablation is a local ablation treatment based on the hypothermia effect,which has been widely used in the treatment of various solid tumors throughout the body.However,low freezing efficiency and insufficient accuracy are the problems in clinical cryoablation therapy which need to be solved urgently.With the continuous progress of nanoscience,various types of nanoparticles have been developed and applied in clinical practice.After being loaded into the target area,the nanoparticles can exert functions such as targeted drug delivery as well as image enhancement,which provides the possibility to break through the current clinical application bottleneck of cryoablation therapy.This paper aims to make a comprehensive review about several currently commonly-used nanoparticles for cryoablation therapy,focusing on their main functions and mechanisms,with the hope that the physicians concerned can get a further detailed understanding of the nanoparticles and lay a solid foundation for conducting in-depth researches and achieving clinical transformation.
关键词
纳米颗粒/冷冻消融术/肿瘤Key words
nanoparticle/cryoablation/tumor引用本文复制引用
出版年
2024
NETL
NSTL
万方数据