CalliSpheres D-TACE与c-TACE治疗原发性肝癌对肝纤维化和肝功能的影响
The effect of CalliSpheres DEB-TACE and c-TACE on liver fibrosis and liver function in treating primary hepatocellular carcinoma
张辉 1张庆桥 2袁磊 1曹生亚 1孟亚会 1王剑宇 1耿冲1
作者信息
- 1. 221000 江苏徐州 徐州市肿瘤医院
- 2. 徐州医科大学附属医院
- 折叠
摘要
目的 比较CalliSpheres载药微球经动脉化疗栓塞术(D-TACE)与传统经动脉化疗栓塞术(c-TACE)治疗原发性肝癌对肝纤维化和肝功能的影响.方法 纳入2020年10月至2022年10月徐州市肿瘤医院诊断为原发性肝癌的患者40例,其中D-TACE 20例,c-TACE 20例.对比两组患者TACE术前、术后5 d和1个月的透明质酸酶(HA)、Ⅲ型前胶原肽(P Ⅲ NP)、Ⅳ型胶原(CⅣ)和层黏蛋白(LN)、丙氨酸转氨酶(ALT)、天冬氨酸转氨酶(AST)、总胆红素(TBil)、白蛋白(Alb)、凝血酶原时间(PT)指标.结果 D-TACE组与c-TACE组技术成功率均为100％,全部患者栓塞后造影均示肿瘤染色完全消失.术后5 d,两组患者HA、LN、P Ⅲ NP、CⅣ均较术前升高(P＜0.05);c-TACE 组 HA、LN、CⅣ值高于 D-TACE 组(P＜0.05).术后1 个月,D-TACE 组 HA 较术前升高(P＜0.05);c-TACE 组 HA、LN 较术前升高(P＜0.05);c-TACE 组 HA、LN值高于D-TACE组(P＜0.05).术后5 d,D-TACE组AST、PT较术前升高,Alb较术前下降(P＜0.05);c-TACE 组 ALT、AST、TBil、PT 较术前升高,Alb 较术前下降(P＜0.05);c-TACE 组 ALT、AST 高于 D-TACE组,Alb低于D-TACE组(P＜0.05).结论 CalliSpheres D-TACE与c-TACE术后均会加重肝纤维化并引起肝功能损伤,CalliSpheres D-TACE对于肝纤维化和肝功能的损伤程度均较c-TACE轻.
Abstract
Objective To compare the effects of CalliSpheres drug-eluting beads transcatheter arterial chemoembolization(DEB-TACE)and conventional TACE(c-TACE)on liver fibrosis and liver function in the treatment of primary hepatocellular carcinoma(HCC).Methods A total of 40 patients diagnosed with HCC at Xuzhou Municipal Cancer Hospital of China between October 2020 and October 2022 were enrolled in this study.According to therapeutic scheme,the patients were divided into DEB-TACE group(n=20)and c-TACE group(n=20).The preoperative,and postoperative 5-day and one-month hyaluronidase(HA),type Ⅲ procollagen peptide(P Ⅲ NP),type Ⅳ collagen(CⅣ)and laminin(LN),alanine aminotransferase(ALT),aspartate aminotransferase(AST),total bilirubin(TBil),albumin(Alb),and prothrombin time(PT)were compared between the two groups.Results The technical success rate was 100％in both groups,and tumor staining completely disappeared immediately after TACE in all patients.The postoperative 5-day levels of HA,LN,P Ⅲ NP,and CⅣ in both groups were remarkably higher than the preoperative ones(P＜0.05).One month after TACE,HA level in the DEB-TACE group was prominently higher than its preoperative value(P＜0.05);HA and LN levels in the c-TACE group were obviously higher than their preoperative values(P＜0.05);and the HA and LN levels in c-TACE group were significantly higher than those in DEB-TACE group(P＜0.05).Five days after TACE,in the DEB-TACE group the AST and PT levels were higher than their preoperative values while the Alb level was lower than its preoperative value(P＜0.05);in the c-TACE group the ALT,AST,TBiL and PT were higher than their preoperative values while the Alb level was lower than its preoperative value(P＜0.05);the ALT and AST levels in the c-TACE group were strikingly higher than those in the DEB-TACE group while Alb level was strikingly lower than that in the DEB-TACE group(P＜0.05).Conclusion Both CalliSpheres DEB-TACE and c-TACE can aggravate liver fibrosis and cause liver function damage.However,the degree of liver fibrosis and liver function damage caused by CalliSpheres DEB-TACE is less than that caused by c-TACE.(J Intervent Radiol,2024,33:259-263)
关键词
原发性肝癌/CalliSpheres载药微球/经动脉化疗栓塞术/肝纤维化/肝功能Key words
primary hepatocellular carcinoma/CalliSpheres bead/transcatheter arterial chemoembo-lization/liver fibrosis/liver function引用本文复制引用
基金项目
江苏大学临床医学科技发展基金(2021)(JLY2021083)
出版年
2024
NETL
NSTL
万方数据