Clinically,intrahepatic cholangiocarcinoma(iCCA)is characterized by high inconspicuousness and high degree of malignancy,and surgical resection is the only radical means,unfortunately,most of the patients have already missed the timing of surgery when the diagnosis of iCCA is confirmed.The main therapeutic goal for unresectable iCCA is to reduce tumor burden,reduce complications and prolong survival.Interventional therapy has outstanding advantages in this regard,it can be used as an alternative or supplement to surgical treatment,and it has already become an increasingly important part in various international guidelines.This paper reviews the currently-used three major categories of interventional therapy for unresectable iCCA(including ablation therapy,transvascular therapy and internal irradiation radiotherapy)and their clinical efficacy.
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