Objective To discuss the curative effect of pulsed radiofrequency combined with nerve block in treating refractory postherpetic neuralgia(PHN).Methods A total of 201 patients with PHN,who were admitted to the hospital to receive treatment between March 2020 and March 2023,were enrolled in this study.Using random number table method,the patients were divided into pulsed radiofrequency group,nerve block group and combination group,with 67 patients in each group.On the basis of routine medication,the patients of pulsed radiofrequency group received nerve pulsed radiofrequency treatment,the patients of nerve block group received nerve block therapy,while the patients of combination group received nerve block followed by nerve root pulsed radiofrequency.At the preoperative(T0),postoperative 7-day(AT7),30-day(AT30)and 90-day(AT90)time point,the short-form of McGill pain questionnaire(SF-MPQ),Pittsburgh Sleep Quality Index(PSQI),levels of pain mediators including β-endorphin,substance P,calcitonin gene-related peptide(CGRP),and levels of inflammatory factors including tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)were determined.The adverse reactions were recorded.Results The postoperative AT7,AT30 and AT90 scores of PRI,VAS,PPI and PSQI,and levels of substance P,CGRP,TNF-α and IL-6 in combination group were lower than those in pulsed radiofrequency group and in nerve block group(all P＜0.05),while level of β-endorphin in combination group was higher than that in the other two groups(P＜0.05).No obvious adverse reactions were observed in all three groups.Conclusion For the treatment of patients with intractable PHN,the combination therapy of pulsed radiofrequency and nerve block is superior to single therapy in improving pain and sleep quality,which may be related to the regulation of the levels of pain mediators and inflammatory factors.
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