不同肝背景下大鼠移植性肝癌肿瘤生长及TACE治疗疗效的差异
The differences in the growth of transplanted hepatocellular carcinoma and the efficacy of TACE in experimental rats with different liver backgrounds
赵航 1宋晓磊 1郑璇 1张煜杰 1周军1
作者信息
- 1. 266000 山东青岛 山东大学齐鲁医院(青岛)介入科
- 折叠
摘要
目的 探索正常肝、脂肪肝、肝硬化背景下大鼠移植性肝癌肿瘤生长时各项指标的差异以及TACE治疗后疗效的不同.方法 将Walker-256腹水瘤细胞种植到正常肝、脂肪肝、肝硬化模型大鼠的肝脏内,并对其行TACE治疗.观察3组不同肝背景大鼠肿瘤生长时及TACE治疗后各项指标的差异.结果 3组不同肝背景肿瘤体积间存在差异,但差异无统计学意义(P＞0.05);治疗前肝功能未见明显差异,治疗后部分肝功能指标脂肪组明显高于硬化组,差异具有统计学意义(P＜0.05);3组微血管密度未见明显差异(P＞0.05),但在同一组内,治疗前后对比3组皆有明显差异(P＜0.05).结论 肿瘤生长过程中:①肿瘤体积存在差异,肝硬化在前期会抑制肿瘤生长,但后期肝硬化大鼠的恶病质状态会加速肿瘤生长;②肝硬化组和脂肪肝组肝功能相似;③微血管密度未见明显差异,但随着肿瘤的增长微血管密度会稍增加.TACE治疗后:①肿瘤体积未见明显差异;②脂肪肝大鼠相对于肝硬化大鼠有较多的肝功能储备;③微血管密度未见明显差异,但栓塞治疗会刺激微血管的增生.
Abstract
Objective To explore the difference of various indicators in the growth of transplanted liver cancer in experimental rats with the background of normal liver,fatty liver and liver cirrhosis,and to discuss the difference in the curative effect after TACE.Methods Walker-256 ascites tumor cells were implanted into the rats with normal liver,fatty liver,and cirrhosis liver separately to establish the experimental liver cancer models.TACE treatment was performed for all experimental rats.All the indicators related to tumor growth and the curative effect of TACE were compared among the three groups of rats with different liver backgrounds.Results In terms of the liver volume,there were differences among the three groups,but the differences were not statistically significant(P＞0.05).No statistically significant differences in the preoperative liver functions existed among the three groups,but some indicators of postoperative liver functions in the fatty liver group were significantly higher than those in the cirrhosis group,and the differences were statistically significant(P＜0.05).No significant differences in microvessel density were observed among the three groups(P＞0.05).However,in the same group statistically significant differences in the above indexes existed between the preoperative values and the preoperative ones(P＜0.05).Conclusion The results of this study indicate that during the growing period of tumor the following three changes can be observed:① There are differences in tumor volume.Cirrhosis may inhibit tumor growth in the early stage,but in the later stage the cachexia of cirrhosis rats may accelerate tumor growth;② There were no significant differences in liver functions between fatty liver and cirrhosis;and ③ There was no significant difference in microvessel density among the rats with different liver backgrounds.However,with the tumor growing,the microvessel density will be slightly increased.After TACE treatment the following three changes can be observed:① There is no significant difference in tumor volume;② Fatty liver rats have more liver function reserve capacity when compared with cirrhotic rats;③ There is no obvious change in microvessel density,although the embolization treatment can stimulate the proliferation of the microvessel.
关键词
肝动脉化疗栓塞/肝癌/脂肪肝/肝硬化/疗效差异/CD34Key words
hepatic artery chemoembolization/liver cancer/fatty liver/cirrhosis/difference in efficacy/CD34引用本文复制引用
出版年
2024
NETL
NSTL
万方数据