Objective To discuss the clinical efficacy of ultrasound-guided microwave ablation(MWA)combined with 125I seed implantation for the treatment of huge liver metastases from colorectal cancer.Methods A total of 76 patients with huge liver metastases,whose diagnosis was confirmed at the Liyang Municipal People's Hospital of China from January 2017 to January 2021,were enrolled in this study.According to the therapeutic scheme,the patients were divided into study group(n=38)and control group(n=38).Ultrasound-guided MW A was adopted for the patients of the control group,while ultrasound-guided MWA combined with 125I seed implantation was carried out for the patients of the study group.The postoperative 6-month disease control rate(DCR),the preoperative and postoperative 6-month tumor marker levels(including CA125 and CA153),and liver function indicators(including AST,ALT and TBiL)were compared between the two groups.In addition,the 2-year progression-free survival(PFS)of both groups was calculated.Results In the study group the DCR was higher than that in the control group,the postoperative tumor marker levels were lower than those in the control group.After treatment,the liver function indicators in both groups were increased when compared with the preoperative values,and PFS in the study group was longer than that in the control group,the differences were statistically significant(all P＜0.05).No statistically significant differences in the postoperative liver function indicators existed between the two groups(P＞0.05).Conclusion For the treatment of huge liver metastases,ultrasound-guided MWA combined with 125I seed implantation can improve the clinical therapeutic efficacy and prolong patient's survival time.
ultrasound-guided microwave ablation125 I radioactive seedhuge liver metastasisdisease control rate
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