Objective To evaluate the clinical curative effect of CT-guided dorsal root ganglion pulsed radiofrequency(DRG-PRF)combined with ozone injection in treating patients with chronic postherpetic neuralgia(PHN).Methods A total of 300 patients with chronic PHN,who were admitted to the Hengshui Municipal People's Hospital of China from December 2020 to August 2023,were enrolled in this study.Using random digital table method,the patients were divided into observation group(n=150,receiving ozone injection+CT-guided DRG-PRF)and control group(n=150,receiving ozone injection alone).The curative effect,infrared thermal imaging index(skin temperature difference between skin lesion area and the corresponding healthy side,i.e.ΔT),sleep quality,pain degree(determined by numerical rating scale,NRS),and pain/inflammatory factors including prostaglandin E2(PGE2),substance P(SP),interleukin-6(IL-6),interleukin-1β(IL-1β)were compared between the two groups.Results The total response rate in the observation group was 92.67％(139/150),which was higher than 83.33％(125/150)in the control group,the difference was statistically significant(P＜0.05).At one d,3 d,7 d,one month and 3 months after treatment,the scores of ΔT,PSQI and NRS in the observation group were lower than those in the control group,and the differences were statistically significant(all P＜0.05).The levels of serum PGE2,SP,IL-6 and IL-1β in the observation group were lower than those in the control group,and the differences were statistically significant(all P＜0.05).Conclusion For the treatment of chronic PHN,CT-guided DRG-PRF combined with ozone injection has reliable clinical effect,it can effectively promote the recovery of skin damage,improve sleep quality,relieve pain,and regulate the levels of pain and inflammatory factors.
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