Cold deformation of Ti45Nb alloy wire was carried out using roller die drawing technology.The effects of cold plastic forming and annealing process on microstructure and mechanical properties of the Ti45Nb alloy wire were studied by means of OM,EBSD and tensile test.The results indicate that with the increase of cold deformation,the grain size of the Ti45Nb alloy wire gradually decreases,the orientation density index of the grains gradually increases,and the<110>silk texture dominates.At the same time,the tensile strength and yield strength of the Ti45Nb alloy wire gradually increase,but its shear strength does not change significantly.The use of water cooling can significantly improve the plasticity of the annealed Ti45Nb alloy wires and prevent cracking during compression deformation.The complete recrystallization temperature of the Ti45Nb wire is around 670 ℃.As the annealing temperature increases,the grain size significantly increases,and the tensile strength and yield strength show an upward trend.