Objective To study the changes and significance of serum Hcy and NT-proBNP levels in patients with chronic heart failure.Methods We selected 102 patients with chronic heart failure as the observation group while another 102 healthy physical examinees during the same period were enrolled as the control group.The serum Hcy and NT-proBNP levels were separately tested in the two groups,and made comparison.Meanwhile,left ventricular ejection fraction(LVEF)was measured.The correlation between serum Hcy,NT-proBNP and LVEF was analyzed.Results The serum Hcy and NT-proBNP levels of the observation group before and after treatment were higher than those of the control group while LVEF was lower than that of the control group with statistically significant differences(P<0.05).Before treatment,the levels of serum Hcy and NT-proBNP in the observation group increased with the upgraded NYHA grading while LVEF decreased;there was a statistically significant difference of each index among the patients with different NYHA grades in pairwise comparison(P<0.05).The levels of serum Hcy and NT-proBNP were negatively correlated with LVEF(P<0.05)before treatment.Conclusion The changes of serum Hcy and NT-proBNP levels could reflect the cardiac function grading and severity of patients with chronic heart failure.
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