SORBS2对心肌病的影响及机制研究进展
Research advances in influence of SORBS2 on cardiomyopathy and its mechanism
韦天鹏 1钱玲玲 1王如兴1
作者信息
- 1. 214023 江苏 无锡,南京医科大学附属无锡人民医院心内科
- 折叠
摘要
SORBS2 是SORBS接头蛋白家族的成员之一,在心脏中高度表达.SORBS2 参与细胞骨架的形成、细胞黏附和信号转导等生理过程.近年来,越来越多的研究表明,SORBS2 对心血管疾病的发生发展具有重要的调控作用.本文在总结SORBS2 蛋白结构与定位的基础上,综述SORBS2 在左室致密化不全性心肌病、脓毒症心肌病等心肌病发生发展中的作用及机制,以期为相关心肌病的预防和治疗提供新思路.
Abstract
SORBS2 is a member of the SORBS adaptor protein family,and is highly expressed in the heart.SORBS2 is involved in the physiological processes such as cytoskeleton formation,cell adhesion and signal transduction.In recent years,more and more studies have shown that SORBS2 plays an important role in regulating the occurrence and development of cardiovascular diseases.Based on summarizing the protein structure and location of SORBS2,this paper reviews the role and mechanism of SORBS2 in the occurrence and development of myocardiopathies including left ventricular non-compaction cardiomyopathy and septic cardiomyopathy,in order to provide new ideas for the prevention and treatment of related myocardiopathies.
关键词
SORBS2/左室致密化不全性心肌病/脓毒症心肌病/扩张型心肌病/致心律失常性心肌病Key words
SORBS2/left ventricular non-compaction cardiomyopathy/septic cardiomyopathy/dilated cardiomyopathy/arrhythmogenic cardiomyopathy引用本文复制引用
基金项目
国家自然科学基金面上项目(82370342)
无锡市"双百"医疗卫生中青年拔尖人才项目(BJ2023005)
出版年
2024
国家科技期刊平台
NSTL
万方数据