鸢尾素在急性心肌梗死中的保护作用研究进展
Research progress of protective effect of irisin in acute myocardial infarction
王洋洋 1谷云飞 1李松森 1王皓1
作者信息
- 1. 471009 河南 洛阳,郑州大学附属洛阳中心医院心血管内科
- 折叠
摘要
鸢尾素是一种由肌肉组织分泌的激素样多肽,由含Ⅲ型纤连蛋白域蛋白 5 经过蛋白水解酶水解后生成,并释放进入外周循环.鸢尾素在急性心肌梗死中具有潜在的保护作用.本文将从减轻氧化应激反应、改善线粒体功能、抑制心肌细胞凋亡、抑制炎症反应、改善微循环等方面,总结近年来鸢尾素在急性心肌梗死中保护作用的相关研究进展,以期为急性心肌梗死的诊疗提供有价值的参考.
Abstract
Irisin is a hormone-like polypeptide secreted by the muscle tissue,which is generated after hydrolysis of fibronectin type Ⅲ domain-containing protein 5 by proteolytic enzymes,and released into the peripheral circulation.Irisin plays a potentially protective role in acute myocardial infarction(AMI).This article summarizes the present research progress of the protective effects of irisin in AMI mainly from the following aspects:reducing oxidative stress response,improving mitochondrial function,inhibiting myocardial apoptosis,inhibiting inflammatory response,improving microcirculation,in order to provide valuable references for the diagnosis and treatment of AMI.
关键词
鸢尾素/急性心肌梗死/氧化应激/线粒体损伤/细胞凋亡Key words
irisin/acute myocardial infarction/oxidative stress/mitochondrial damage/apoptosis引用本文复制引用
基金项目
河南省自然科学基金(232300420247)
河南省科技攻关计划(212102310810)
出版年
2024
国家科技期刊平台
NSTL
万方数据