心房颤动患者肾功能恶化的危险因素研究进展
Risk factors for renal function deterioration in atrial fibrillation patients:a research review
蓝子尹 1郭军1
作者信息
- 1. 510630 广东 广州,暨南大学附属第一医院心内科
- 折叠
摘要
心房颤动(简称房颤)是临床常见的心律失常.肾功能损害为房颤患者常见的伴发疾病,会增加患者脑卒中、血栓栓塞以及出血的风险.然而,目前对于房颤患者肾功能恶化的病理生理机制仍未阐明.早期识别肾功能恶化的高危因素并采取干预措施,可能会降低房颤患者肾功能恶化的发生率.本文结合最新的研究进展,从二尖瓣舒张早期血流峰值速度与整体舒张期应变率比值、左心房内径、踝臂指数、CHA2DS2-VASc评分以及抗凝药物使用对房颤患者肾功能恶化的影响等方面进行综述.
Abstract
Atrial fibrillation(AF)is a type of common arrhythmia in clinical practice.Renal dysfunction is a commonly concomitant disease in AF patients which increases their risk of stroke,thromboembolism,and bleeding.However,the current understanding of the pathophysiological mechanisms underlying renal function deterioration in AF patients remains incomplete.The early identification of high-risk factors for renal function deterioration and the implementation of intervention measures may contribute to a reduced incidence of renal function decline in patients with AF.This article reviews the latest research progress,focusing on the impact of early diastolic blood peak flow velocity of the mitral valve to global diastolic strain rate ratio,left atrial diameter,ankle-brachial index,CHA2DS2-VASc score,and use of anticoagulant drugs on renal function deterioration in patients with AF.
关键词
心房颤动/肾功能/左心房内径/踝臂指数/CHA2DS2-VASc评分Key words
atrial fibrillation/renal function/left atrial diameter/ankle-brachial index/CHA2DS2-VASc score引用本文复制引用
基金项目
广州市科技计划重点研发项目(202103000010)
暨南大学附属第一医院临床前沿新技术项目(JNU1AF-CFTP-2022-a01218)
出版年
2024
国家科技期刊平台
NSTL
万方数据