Influencing factors of gastrointestinal bleeding in acute myocardial infarction patients with dual antiplatelet therapy with aspirin and ticagrelor after percutaneous coronary intervention
Objective To investigate the probability and influencing factors of gastrointestinal bleeding in acute myocardial infarction(AMI) patients with dual antiplatelet therapy with aspirin and ticagrelor after percutaneous coronary intervention (PCI). Methods We selected 1200 patients who had undergone PCI due to AMI, and had received dual antiplatelet therapy with aspirin and ticagrelor after PCI. They were divided into bleeding group and non-bleeding group according to the presence or absence of gastrointestinal bleeding. The clinical data were compared between the two groups. The risk factors of gastrointestinal bleeding after PCI in AMI patients were analyzed by univariate and binary multivariate Logistic analysis. Results Among the 1200 AMI patients treated by PCI, gastrointestinal bleeding occurred in 38 cases with an incidence rate of 3.17％. Univariate analysis results showed that creatinine, age, and the proportion of patients with history of peptic ulcer and smoking history in the bleeding group were all significantly higher than those in the non-bleeding group, while hemoglobin and the proportion of patients taking proton pump inhibitors were significantly lower than those in the non-bleeding group (all P<0.05). Binary multivariate Logistic regression analysis showed that age, smoking history, use of proton pump inhibitors, and hemoglobin were all independent influencing factors for gastrointestinal bleeding after PCI in AMI patients with dual antiplatelet therapy with aspirin and ticagrelor (all P<0.01). Conclusion There is a high probability of gastrointestinal bleeding in AMI patients with dual antiplatelet therapy with aspirin and ticagrelor after PCI. Gastrointestinal bleeding could be influenced by various factors among these patients, and corresponding countermeasures should be formulated clinically, in order to reduce the occurrence of gastrointestinal bleeding and improve the prognosis of AMI patients.
万方数据
维普
