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要高度重视免疫检查点抑制剂相关心血管不良反应的诊治

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免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)在肿瘤免疫治疗中占据了核心地位,极大地改善了肿瘤患者的预后。但随着临床实践的不断深入,发现ICIs在激活免疫系统的同时,还会引起各种不良反应,尤其是导致多种心血管毒性,使心血管死亡率升高。本文综述了 ICIs诱发心血管毒性的临床表现形式、发生机制、诊断及防治方法等,为预防心血管损伤、改善心脏功能提供依据。
Pay attention to diagnosis and treatment of cardiovascular adverse reactions associated with immune checkpoint inhibitors
Immune checkpoint inhibitors(ICIs)occupy a core position in tumor immunotherapy,and greatly improve the prognosis of tumor patients.However,with the deepening of clinical practice,it has been found that ICIs can not only activate the immune system,but also cause many adverse reactions,especially leading to a variety of cardiovascular toxicity and increased cardiovascular mortality.This paper reviews the clinical manifestations,pathogenesis,diagnosis and treatment,etc.of ICIs-induced cardiovascular toxicity,which provides evidences for preventing cardiovascular injury and improving cardiac function.

immune checkpoint inhibitorcardiotoxicityimmune-related adverse eventcancer immunotherapycardio-oncology

詹洪吉、刘红霞、谭梦琴、王福军

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416000 湖南吉首,湘西土家族苗族自治州人民医院心内科

418000 湖南怀化,湖南医药学院总医院急救医学中心

571100 海南海口,海南省老年病医院心脏中心

免疫检查点抑制剂 心脏毒性 免疫相关不良事件 肿瘤免疫疗法 肿瘤心脏病学

2024

实用心电学杂志
江苏大学

实用心电学杂志

影响因子:0.648
ISSN:2095-9354
年,卷(期):2024.33(6)