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免疫检查点抑制剂相关心包疾病研究进展

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免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)能阻断肿瘤的免疫逃逸,已被广泛应用于多种恶性肿瘤的治疗,但其导致的免疫相关不良事件也随之增多.心包疾病是常见的ICIs相关心血管不良反应,在急性期致死率较高.本文介绍了 ICIs相关心包疾病的流行病学、致病机制、临床特点、治疗原则等方面的研究进展,以提高临床医生对该病的认识.
Research advances in pericardial diseases associated with immune checkpoint inhibitors
Immune checkpoint inhibitors(ICIs)have been widely applied in the clinical treatment of various malignant tumors by blocking the tumor immune escape.However,it is followed by increasing immune-related adverse events caused by ICIs.As common ICIs-related cardiovascular adverse reactions,pericardial diseases lead to a relatively high mortality at the acute phase.This article introduces the research progress in recent years on the epidemiology,pathogenesis,clinical characteristics,and treatment principles of ICIs-related pericardial diseases,in order to deepen the clinicians'understandings of this disease.

immune checkpoint inhibitorpericardial diseasecardiovascular toxicitycancer immunotherapy

张舟、罗丹、谭梦琴、王福军

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416000 湖南吉首,湘西土家族苗族自治州人民医院心内科

418000 湖南怀化,湖南医药学院总医院急救医学中心

571100 海南海口,海南省老年病医院心脏中心

免疫检查点抑制剂 心包疾病 心血管毒性 肿瘤免疫疗法

2024

实用心电学杂志
江苏大学

实用心电学杂志

影响因子:0.648
ISSN:2095-9354
年,卷(期):2024.33(6)