实用心电学杂志2024,Vol.33Issue(6) :553-556.DOI:10.13308/j.issn.2095-9354.2024.06.003

免疫检查点抑制剂相关心包疾病研究进展

Research advances in pericardial diseases associated with immune checkpoint inhibitors

张舟 罗丹 谭梦琴 王福军
实用心电学杂志2024,Vol.33Issue(6) :553-556.DOI:10.13308/j.issn.2095-9354.2024.06.003

免疫检查点抑制剂相关心包疾病研究进展

Research advances in pericardial diseases associated with immune checkpoint inhibitors

张舟 1罗丹 1谭梦琴 2王福军3
扫码查看

作者信息

  • 1. 416000 湖南吉首,湘西土家族苗族自治州人民医院心内科
  • 2. 418000 湖南怀化,湖南医药学院总医院急救医学中心
  • 3. 571100 海南海口,海南省老年病医院心脏中心
  • 折叠

摘要

免疫检查点抑制剂(immune checkpoint inhibitors,ICIs)能阻断肿瘤的免疫逃逸,已被广泛应用于多种恶性肿瘤的治疗,但其导致的免疫相关不良事件也随之增多.心包疾病是常见的ICIs相关心血管不良反应,在急性期致死率较高.本文介绍了 ICIs相关心包疾病的流行病学、致病机制、临床特点、治疗原则等方面的研究进展,以提高临床医生对该病的认识.

Abstract

Immune checkpoint inhibitors(ICIs)have been widely applied in the clinical treatment of various malignant tumors by blocking the tumor immune escape.However,it is followed by increasing immune-related adverse events caused by ICIs.As common ICIs-related cardiovascular adverse reactions,pericardial diseases lead to a relatively high mortality at the acute phase.This article introduces the research progress in recent years on the epidemiology,pathogenesis,clinical characteristics,and treatment principles of ICIs-related pericardial diseases,in order to deepen the clinicians'understandings of this disease.

关键词

免疫检查点抑制剂/心包疾病/心血管毒性/肿瘤免疫疗法

Key words

immune checkpoint inhibitor/pericardial disease/cardiovascular toxicity/cancer immunotherapy

引用本文复制引用

出版年

2024
实用心电学杂志
江苏大学

实用心电学杂志

影响因子:0.648
ISSN:2095-9354
段落导航相关论文