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内含子miRNA反馈调节宿主基因的表达与功能研究进展

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miRNA是近年来发现的一类重要的基因表达调控因子.研究发现,许多miRNA位于编码蛋白基因(宿主基因)的内含子中,称为内含子miRNA.现有的证据表明,大多数内含子miRNA和它们的宿主基因表达一致,提示这些内含子miRNA参与宿主基因在功能和表达上的调控,本文就这方面的最新研究进展做一综述.
Advances in research on intronic miRNAs feedback regulation of their host genes
miRNAs were discovered less than a decade ago, and have emerged as important regulators of gene expression in mammals. A large number of miRNAs have been identified to be located within the intronic regions of protein-encoding genes(host genes) and called intronic miRNAs. The intronic miRNAs may play a key role in regulating the expression and function of their host genes due to the fact that most of them are co-expressed with the host genes. In this paper, the recent advances on the research on potential relationship between intronic miRNAs and their host genes are reviewed.

miRNAintronshost genefeedback regulation

黄宝春、曹国军、邵宁生

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军事医学科学院基础医学研究所,北京,100850

miRNA 内含子 宿主基因 反馈调节

国家重点基础研究发展规划(973计划)国家自然科学基金面上项目

2005CB72460030600110

2009

军事医学
军事医学科学院

军事医学

CSTPCDCSCD北大核心
影响因子:0.586
ISSN:1674-9960
年,卷(期):2009.33(6)
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