摘要
昼夜节律是生物在进化过程中形成的适应地球自转的生物节律之一,表现为机体在内部生物钟控制下产生的约为24h的循环周期生物节律,协调睡眠/觉醒、体温调节、内分泌时相等活动,长期昼夜节律失调可引起代谢紊乱、胃肠疾病、神经退行性疾病等患病风险增高.水生生物斑马鱼(Danio rerio)作为典型的模式动物,已被广泛应用于昼夜节律实验研究中.该文详细介绍了斑马鱼生物钟的运行机制、输入系统的影响因素、生物钟基因及通路、生理性输出,总结了在昼夜节律研究中的应用及优势,并展望了未来研究发展,以期为昼夜节律调控机制研究和相关药物研发以及疾病治疗策略提供理论支持.
Abstract
Circadian rhythm is one of the biorhythms formed by organisms in the process of evolution to adapt to the rotation of the earth,which is manifested as a cyclical biorhythm of about 24 hours produced by the body under the control of the internal biological clock,coordinating sleep/wakefulness,body temperature regulation,endocrine time and other activities.Long-term circadian rhythm disorders can cause increased risk of metabolic disorders,gastrointestinal diseases,neurodegenerative diseasesand other illnesses.As a typical model animal,the aquatic organism zebrafish(Danio rerio)has been widely used in experimental studies of circadian rhythm.This paper introduces in detailthe operating mechanism of zebrafish circadian clock,the influencing factors of the input system,the genes and pathways of the circadian clock,and the physiological output,summarizes the application and advantages in circadian rhythm research,finally looks forward to future research and development,in order to provide theoretical support for circadian rhythm regulation mechanism research,related drug development and disease treatment strategies.
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