Pathology and therapeutic potential of astrocytes in radiation-induced brain injury
Radiation-induced brain injury is a severe brain injury caused by ionizing radiation to normal brain tissue.It is manifested as cognitive dysfunction,decreased learning and memory ability and can even lead to dementia.The treatment of existing drugs for radiation-induced brain injury are far from effective with poor prognosis.Ionizing radiation induces pathological activation of astrocytes,which aggravates the process of radiation-induced brain injury by inducing neuroin-flammation and destroying the blood-brain barrier.Here we review the physiological and pathological functions of astrocytes,then analyze the pathological changes and cellular mechanisms of astrocytes involved in radiation-induced brain injury.Furthermore,the therapeutic potential of astrocytes in radiation-induced brain injury is discussed,which is expected to provide reference for finding more approaches to radiation-induced brain injury and exploring new therapeutic targets and methods.
国家科技期刊平台
NSTL
万方数据
