相思子毒素的分析检测技术及毒性机制与解毒对抗措施研究进展
Research progress in analysis and detection techniques,toxicity mechanism,and detoxification countermeasures of Abrin
肖兰 1王闯 1刘佳 2刘璐瑶 1郭磊 3唐丽4
作者信息
- 1. 中央民族大学药学院民族医药教育部重点实验室,北京 100081;军事科学院军事医学研究院毒物分析实验室,北京 100850
- 2. 军事科学院军事医学研究院毒物分析实验室,北京 100850;河北科技大学药学院,石家庄 050091
- 3. 军事科学院军事医学研究院毒物分析实验室,北京 100850
- 4. 中央民族大学药学院民族医药教育部重点实验室,北京 100081
- 折叠
摘要
相思子毒素是目前已知毒性最强的植物毒素蛋白,受到国际《禁止化学武器公约》和《禁止生物及毒素武器公约》共同关注,亟须有效的检测和解毒对抗措施,以应对其对于人类健康和公共安全的潜在威胁.该文在文献聚类研判的基础上,结合对相思子毒素的多种亚型结构的认识,对其分析检测技术、毒性机制、解毒对抗措施进行了全面综述,最后阐述了该领域的难点及发展趋势.目前主要的相思子毒素分析检测技术包括亲和分析、理化分析以及活性检测技术三大类,亟须发展灵敏特异准确的结构与活性测定技术方法,以准确厘清毒素威胁.目前尚无有效解毒剂,治疗仅为对症治疗.研发中和抗体仍然是对抗其中毒最有潜力的手段.
Abstract
Abrin,the most lethal plant-derived toxin known today,has attracted widespread attention from both the International Chemical Weapon Convention and the Biological and Toxin Weapons Convention.There is an urgent demand for the development of efficient detection and detoxification countermeasures against Abrin to adress its potential threats to human health and public safety.This review,based on clustering analysis of literature and on knowledge of the structures of various subtypes of Abrin,provides an overview of the analysis and detection techniques,the mechanism of toxicity,and detoxification countermeasures against Abrin.It concludes with an examination of the challenges and emerging trends in this field.The main analysis and detection techniques of Abrin include affinity-based analysis,physico-chemical-based analysis,and activity-based detection techniques.The challenges and developments in this field are also outlined.There is a pressing need to establish sensitive,specific,and accurate methods of measurement that are tailored to the structure and activity of Abrin in order to precisely assess and mitigate the toxin threat.Unfortunately,no effective antidotes have been deployed so far,with medical treatments confined to symptomatic care.Research and development of neutralizing antibodies remain stands as the most promising strategy for counteracting Abrin intoxication.
关键词
相思子毒素/分析检测/毒性机制/解毒对抗措施Key words
Abrin/analysis and detection/toxicity mechanism/detoxification countermeasures引用本文复制引用
基金项目
国家自然科学基金面上项目(21974152)
国家自然科学基金(81873397)
出版年
2024
国家科技期刊平台
NSTL
万方数据