嗅觉刺激在改善认知功能障碍中的研究进展
Research progress in roles of olfactory stimulation in improving cognitive dysfunction
朱为 1吴昊伟 1徐东刚1
作者信息
- 1. 军事科学院军事医学研究院,北京 100850
- 折叠
摘要
认知功能障碍,主要由神经退行性疾病引发,已成为日益严峻的健康问题.气味分子通过嗅觉信号通路,能够绕过血脑屏障,不经丘脑中转,直接作用于内嗅皮质、海马体和杏仁核等与认知功能相关的大脑区域.这些用于调控认知的嗅觉刺激分子主要来源于天然植物精油,具有挥发性强、不良反应少、来源丰富等特点.因此,嗅觉刺激在改善认知功能障碍中的研究与应用逐渐受到广泛关注.该文概述了嗅觉传导通路与大脑认知区域的联系,梳理了通过嗅觉刺激改善认知功能障碍的天然植物精油及其作用机制,以期为嗅觉刺激在改善认知功能方面的应用提供借鉴.
Abstract
Cognitive dysfunction,predominantly a consequence of neurodegenerative disorders,is a burgeoning health issue.Odor molecules have the unique ability to circumvent the blood-brain barrier through the olfactory pathway,exerting a direct influence on cognitive-related brain regions including the entorhinal cortex,hippocampus,and amygdala,without transiting through the thalamus.These olfactory molecules,mostly sourced from natural plant essential oils,are character-ized by significant volatility,minimal adverse reactions,and abundant availability.Hence,research into and applications of olfactory stimulation in improving cognitive dysfunction have raised widespread concerns.This article reviews the rela-tionship between the olfactory pathway and cognitive brain regions,and explores the mechanism by which natural plant es-sential oils alleviate cognitive dysfunction through olfactory stimulation in order to provide a reference for improving cogni-tive function via olfactory stimulation.
关键词
嗅觉通路/嗅觉刺激/植物精油/挥发性有机物/认知功能障碍Key words
olfactory pathway/olfactory stimulation/plant essential oils/volatile organic compounds/cognitive dys-function引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据